Radioiodinated analogs of xylamine: N??(2??chloroethyl)??N??ethyl??2??[125I] iodobenzylamine and N, N??diethyl??2??[125I] iodobenzylamine as potential tools for …

…, JE Ombetta??Goka, JC Besnard…

Index: Branger; Garreau; Frangin; Chalon; Dubois; Dognon; Ombetta-Goka; Besnard; Guilloteau Journal of Labelled Compounds and Radiopharmaceuticals, 1995 , vol. 36, # 7 p. 685 - 699

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Abstract

Abstract In order to improve the scintigraphy and radiotherapy of neuroendocrine tumors we synthesized two radioiodinated benzylamines [N-(2-chloroethyl)-N-ethyl-2-[125 I] iodobenzylamine and N, N-diethyl-2-[125 I] iodobenzylamine], analogs of xylamine [N-(2- chloroethyl)-N-ethyl-2-methylbenzylamine]. Xylamine is an irreversible inhibitor of uptake and accumulation of noradrenaline. The two unlabelled iodinated derivatives [N-(2- ...