Tetrahedron

A formal method for the de-N, N-dialkylation of Sommelet–Hauser rearrangement products

…, R Sato, K Takedachi, H Iwamoto, E Hasegawa

Index: Tayama, Eiji; Sato, Ryota; Takedachi, Keisuke; Iwamoto, Hajime; Hasegawa, Eietsu Tetrahedron, 2012 , vol. 68, # 24 p. 4710 - 4718

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Citation Number: 9

Abstract

Selective amine de-alkylation enables the conversion of Sommelet–Hauser rearrangement products into 2-aryl-2-bromoacetic acid derivatives. These compounds are valuable synthetic intermediates in the synthesis of α-aryl-α-amino or α-aryl-β-amino acid derivatives. The method presented herein is a formal de-N, N-dialkylation of Sommelet–Hauser rearrangement products.