Synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from Klebsiella pneumonia and Pseudomonas aeruginosa

…, P Vella, G Schenk, RHA El-hameed

Index: Mohamed, Mosaad S.; Hussein, Waleed M.; McGeary, Ross P.; Vella, Peter; Schenk, Gerhard; Abd El-Hameed, Rania H. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 6075 - 6082

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Citation Number: 28

Abstract

There are currently no clinically useful inhibitors against metallo-β-lactamases (MBLs), enzymes that confer resistance against a broad spectrum of commonly used antibiotics and that are produced by an increasing number of bacterial pathogens. New pyrrole derivatives were synthesized and assayed for their inhibitory effect on the catalytic activity of the IMP-1 MBL from Pseudomonas aeruginosa and Klebsiella pneumoniae. Six compounds tested ( ...