Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

D Biondini, L Brinchi, R Germani…

Index: Biondini, Daniele; Brinchi, Lucia; Germani, Raimondo; Goracci, Laura; Savelli, Gianfranco Letters in Organic Chemistry, 2010 , vol. 7, # 1 p. 39 - 44

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Citation Number: 4

Abstract

Ionic liquid 1, 3-dimethylimidazolium methanesulfonate was used to prepare α-amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.