An activated trifluoromethyl group as a new synthon for 4, 5??dihydro??1H??imidazole and 1, 4, 5, 6??tetrahydropyrimidine systems

…, SE Patterson, L Strekowski

Index: Wydra, Roman L.; Patterson, Steven E.; Strekowski, Lucjan Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 3 p. 803 - 805

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Citation Number: 19

Abstract

Abstract Treatment of 4-(trifluoromethyl) benzenamine 1a and 2-(trifluoromethyl) benzamine 1b with lithium 2-aminoethylamide gives 2-(4-aminophenyl)-4, 5-dihydro-1H-imidazole 3a and 2-(2-aminophenyl)-4, 5-dihydro-1H-imidazole 3b, respectively. Similar reactions of 1a and 1b with lithium 3-aminopropylamide produce the respective 2-(aminophenyl)-1, 4, 5, 6- tetrahydropyrimidines 4a and 4b. 3-(Trifluoromethyl) benzenamine 1c is recovered ...