One-flask phosphorylative coupling of two alcohols by means of aryl cyclic enediol phosphates. Phenoxide ion catalysis of phosphorylations in aprotic solvents

F Ramirez, JF Marecek, H Tsuboi…

Index: Ramirez,F. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 771 - 778

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Citation Number: 10

Abstract

Results Preparation of 2-Aryloxy-4, 5-dimethyl-1, 3, 2-dioxa-phosphole 2-Oxides (4-7). Phenols react with the pyrophosphate 3 by displacement at phosphorus with ring retentionS4 It has now been found that tertiary amines, which are used to neutralize the acidic by-product of this reaction, X= P (O) OH, exert also a catalytic effect. The approximate half-time for the reaction of equimolar amounts of CsH50I. I with 3, in 0.2 M CDC13 (25'C), ...