Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation

JF Liu, P Ye, K Sprague, K Sargent, D Yohannes…

Index: Liu, Ji-Feng; Ye, Ping; Sprague, Kevin; Sargent, Katie; Yohannes, Daniel; Baldino, Carmen M.; Wilson, Christopher J.; Ng, Shi-Chung Organic Letters, 2005 , vol. 7, # 15 p. 3363 - 3366

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Citation Number: 82

Abstract

Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8- hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.

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