Discovery of the novel antithrombotic agent 5-chloro-N-({(5 S)-2-oxo-3-[4-(3-oxomorpholin-4-yl) phenyl]-1, 3-oxazolidin-5-yl} methyl) thiophene-2-carboxamide (BAY …

…, KH Schlemmer, P Reinemer…

Index: Aitken, R. Alan; Bibby, Michael C.; Bielefeldt, Florian; Double, John A.; Laws, Andrea L.; Mathieu, Anne-Laure; Ritchie, Robert B.; Wilson, David W. J. Archiv der Pharmazie, 1998 , vol. 331, # 12 p. 405 - 411

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Citation Number: 351

Abstract

... oxazolidinone ring was essential [IC 50 value of 0.7 nM for (S)-enantiomer 8 5 vs 2.3 μM for (R)-enantiomer 16 ... activity was obtained for the morpholinone series than for 11, which correlated well with the lower concentration required to double the PT ... 5, 0.40 c, 0.30 c, 0.9 c, 60 d, 1.3 ...