Synthesis and testing of novel phenyl substituted side-chain analogues of classical cannabinoids

M Krishnamurthy, AM Ferreira, BM Moore

Index: Krishnamurthy, Mathangi; Ferreira, Antonio M.; Moore II, Bob M. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3487 - 3490

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Citation Number: 27

Abstract

A series of novel phenyl substituted side-chain analogues of classical cannabinoids were synthesized and their CB1 and CB2 binding affinities were evaluated relative to Δ8-THC and compound 2. CB1 and CB2 binding assays indicate that the dimethyl and ketone analogues (3) and (6) display selectivity for the CB2 receptor in comparison to Δ8-THC and compound 2. This study provides newer insights into the geometrical and functional group ...