A Facile Synthesis of Substituted 2-Alkylquinolines through [3+ 3] Annulation between 3-Ethoxycyclobutanones and Aromatic Amines at Room Temperature
G Shan, X Sun, Q Xia, Y Rao
Index: Shan, Gang; Sun, Xiuyun; Xia, Qian; Rao, Yu Organic Letters, 2011 , vol. 13, # 21 p. 5770 - 5773
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Citation Number: 19
Abstract
An efficient single-step approach toward the synthesis of 2-alkylquinolines is described. Through a Lewis acid mediated [3+ 3] annulation reaction between 3-ethoxycyclobutanones and aromatic amines, a variety of multisubstituted 2-alkylquinoline derivatives were prepared regioselectively at room temperature.
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