Journal of pharmaceutical sciences

A novel prodrug strategy for β??dicarbonyl carbon acids: Syntheses and evaluation of the physicochemical characteristics of C??phosphoryloxymethyl (POM) and …

SS Dhareshwar, VJ Stella

Index: Dhareshwar, Sundeep S.; Stella, Valentino J. Journal of Pharmaceutical Sciences, 2010 , vol. 99, # 6 p. 2711 - 2723

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Citation Number: 8

Abstract

Abstract The C-phosphoryloxymethyl (POM) and phosphoryloxymethyloxymethyl (POMOM) prodrugs resulting from derivatization at the reactive α-carbon of β-dicarbonyl carbon acid drugs represent a unique approach for improving their chemical stability and aqueous ...