Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent

B Liang, M Huang, Z You, Z Xiong, K Lu…

Index: Liang, Bo; Huang, Mengwei; You, Zejin; Xiong, Zhengchang; Lu, Kui; Fathi, Reza; Chen, Jiahua; Yang, Zhen Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 6097 - 6100

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Citation Number: 133

Abstract

The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et3N as a base. The developed method was successfully applied to the synthesis of flavones.