1-Aryl-tetrahydroisoquinoline analogs as active anti-HIV agents in vitro

P Cheng, N Huang, ZY Jiang, Q Zhang…

Index: Cheng, Pi; Huang, Ning; Jiang, Zhi-Yong; Zhang, Quan; Zheng, Yong-Tang; Chen, Ji-Jun; Zhang, Xue-Mei; Ma, Yun-Bao Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 7 p. 2475 - 2478

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Citation Number: 49

Abstract

A series of 1-aryl-6, 7-dihydroxyl (methoxy)-1, 2, 3, 4-tetrahydroisoquinolines (compounds 1– 36) were synthesized via Pictet–Spengler cyclization. All the synthesized compounds were assayed for activities against HIV-1IIIB in C8166 cell cultures by MTT method for the first time. The results of the anti-HIV screening revealed that 6, 7- dihydroxytetrahydroisoquinolines possessed higher selective index than 6, 7-dimethoxyl ...