Total Synthesis of (±)-Cephalosol via Silyl Enol Ether Acylation
A Arlt, U Koert
Index: Arlt, Alexander; Koert, Ulrich Synthesis, 2010 , # 6 p. 917 - 922
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Citation Number: 3
Abstract
Abstract An efficient total synthesis of (±)-cephalosol is reported. Key steps are the acylation of a silyl enol ether with monomethyl oxalyl chloride and the subsequent acid-mediated ring closure to the isocoumarin structure. A chemoselective allylation and the conversion of the olefin into a methyl acetate were applied to install the γ-lactone moiety.
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