Synthese et etude pharmacologique de pyridazino (4, 5-b) carbazoles.

…, D LADUREE, M CUGNON DE SEVRICOURT…

Index: Landelle; Laduree; Cugnon de Sevricourt; Robba Chemical and pharmaceutical bulletin, 1989 , vol. 37, # 10 p. 2679 - 2682

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Citation Number: 11

Abstract

Cyclization reaction of hydrazine with carbazole-2, 3-methyl dicarboxylates gave 1, 4-dioxo- 1, 2, 3, 4-tetrahydropyridazino [4, 5-b] carbazoles. Chlorodehydroxylation provided 1, 4- dichloropyridazino [4, 5-b] carbazoles and nucleophilic substitution gave 1, 4-dialkoxy pyridazino [4, 5-b] carbazoles. These compounds were tested for cytotoxic activity against L1210 leukemia in mice.