10-(Alkylamino)-4H-thieno [3, 4-b][1, 5] benzodiazepines. A novel class of potential neuroleptic agents

JB Press, CM Hofmann, NH Eudy…

Index: Press,J.B. et al. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 725 - 731

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Citation Number: 25

Abstract

An intensive investigation of the structural requirements for CNS activity of the title compounds was undertaken. A synthesis of the precursor dihydro-lOH-thien0 [3, 4-b][1, 5] benzodiazepin-10-ones was achieved and three routes for their conversion to the title compounds were developed. The compounds were tested for neuroleptic activity by means of the blockade of d-amphetamine lethality in aggregated mice and/or effects on locomotor ...