Benzo [4, 5] imidazo [2, 1-a] phthalazines: I. substituted o-nitrophenylhydrazines in the synthesis of phthalazin-1 (2H)-ones

VA Kuznetsov, KM Shubin, AA Shchipalkin…

Index: Kuznetsov; Shubin; Shchipalkin; Teplyakov; Petrov Russian Journal of Organic Chemistry, 2008 , vol. 44, # 5 p. 731 - 735

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Abstract

Abstract Efficient cyclization procedure was developed for 2-nitro-, 2, 4-dinitro-, 2-nitro-5- chloro-, and 4, 5-dichloro-2-nitrophenylhydrazines with 2-acylbenzoic acids by heating the reagents in a mixture of of concentrated sulfuric acid and ethanol. A series of new phthalazin- 1-ones was obtained with a substituted 2-nitrophenyl group in the position 2 and various substituents in the position 4.