Synthesis and Potential Antipsychotic Activity of 1H-Imidazo [1, 2-c] pyrazolo [3, 4-e] pyrimidines

HA DeWald, NW Beeson, FM Hershenson…

Index: DeWald; Beeson; Hershenson; Wise; Downs; Heffner; Coughenour; Pugsley Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 454 - 461

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Citation Number: 18

Abstract

In previous papers we described two series of compounds that lack dopamine antagonist activity and exhibit preclinical profiles suggestive of antipsychotic efficacy without extrapyramidal side effect p~ tential.~,~ As part of this continuing effort, we now report the investigation of a series of novel imidazopyrazolopyrimidines with preclinical effects that resemble those of antipsychotic drugs. This work was based, in part, on our earlier ...