Reaction of 4-substituted benzaldehydes and acetophenones with chloroacetonitrile

J Svoboda, Z Kocfeldová…

Index: Svoboda, Jiri; Kocfeldova, Zuzana; Palecek, Jaroslav Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 822 - 832

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Citation Number: 18

Abstract

Abstract Under conditions of phase-transfer catalysis or in homogeneous solution of potassium tert-butoxide the title compounds give stereoisomeric mixtures of substituted 2, 3- epoxy nitriles III and IV. Alkaline hydrolysis of epoxy nitriles IV afforded the corresponding 2- arylpropanals in low yields. On treatment with methanol and potassium carbonate, epoxy nitriles III and IV were converted into epoxy esters in good yields.