The Journal of Organic Chemistry

Enzyme-catalyzed enantioconvergent lactonization of. gamma.-hydroxy diesters in organic solvents

AL Gutman, T Bravdo

Index: Gutman, Arie L.; Bravdo, Tamar Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4263 - 4265

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Citation Number: 53

Abstract

Summary: A strategy has been developed for the enantioconvergent lactonization of symmetrical hydroxy diesters which exploits the prochiral stereospecificity of lipases in organic solvents. Using this approach, prochiral y-hydroxypimelate diesters (2) were converted into either enantiomer of y-butyrolactone y-3-propionates (3).