Bioorganic & medicinal chemistry

Synthesis of benzo-annulated tryptanthrins and their biological properties

JL Liang, SE Park, Y Kwon, Y Jahng

Index: Liang, Jing Lu; Park, So-Eun; Kwon, Youngjoo; Jahng, Yurngdong Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 16 p. 4962 - 4967

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Citation Number: 18

Abstract

A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redox properties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo- annulation on quinazolin-4 (3H)-one moiety. Although the benzo-annulation on quinazolin-4 (3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the ...