Drugs derived from cannabinoids. 1. Nitrogen analogs, benzopyranopyridines and benzopyranopyrroles

…, FE Granchelli, RK Razdan, JK Keller…

Index: Pars; Granchelli; Razdan; Keller; Teiger; Rosenberg; Harris Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 445 - 454

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Citation Number: 58

Abstract

Various nitrogen analogs of A6aJOatetrahydrocannabinol were synthesized by a general procedure described in an earlier communication. Minimum effective doses (MEDds) and lethal doses (LDm's) were determined by a modified Irwin mouse screen after iv administration of compounds in PEG 200. The most potent compounds were the propargyl (5t), allyl (5m), and chloroallyl (50-q) derivatives. Overt behavioral effects (CNS ...