Organic letters

A Highly Facile and Efficient One-Step Synthesis of N 6-Adenosine and N 6-2'-Deoxyadenosine Derivatives

ZK Wan, E Binnun, DP Wilson, J Lee

Index: Wan, Zhao-Kui; Binnun, Eva; Wilson, Douglas P.; Lee, Jinbo Organic Letters, 2005 , vol. 7, # 26 p. 5877 - 5880

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Citation Number: 56

Abstract

A highly facile and efficient one-step synthesis of N 6-adenosine and N 6-2'- deoxyadenosine derivatives has been developed. Treatment of inosine or 2'-deoxyinosine, without protection of sugar hydroxyl groups, with alkyl or arylamines, in the presence of BOP and DIPEA in DMF, led to the formation of N 6-adenosine and N 6-2'-deoxyadenosine derivatives in good to excellent yields. Carcinogenic polyaromatic hydrocarbon (PAH) N 6 ...