Structure—activity considerations in kinetics and mechanism of chlorine exchange between chloramine??T and secondary amines

H Dannan, A Hussain, PA Crooks…

Index: Dannan; Hussain; Crooks; Dittert Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 7 p. 657 - 660

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Citation Number: 2

Abstract

Abstract To study the mechanism of N-chlorination of secondary amines by chloramine-T, the kinetics of the reactions of some aromatic-substituted analogues of N- chlorobenzenesulfonamide with various secondary amines were determined. The importance of amine basicity and reactivity of the N [BOND] Cl bond of the N- chlorobenzenesulfonamide was also assessed. The results indicate that a mechanism ...