C 8-Arylguanine and C 8-aryladenine formation in calf thymus DNA from arenediazonium ions

…, R Rao, X Shi, T Lawson, C Kolar, B Toth

Index: Gannett, Peter M.; Powell, Jeannine H.; Rao, Ramakrishna; Shi, Xiangling; Lawson, Terence; Kolar, Carol; Toth, Bela Chemical Research in Toxicology, 1999 , vol. 12, # 3 p. 297 - 304

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Citation Number: 53

Abstract

Arylhydrazides, arylhydrazines, and N-alkyl-N-arylnitrosamines are metabolized to arenediazonium ions which yield C 8-arylpurine adducts in calf thymus and cellular DNA. The mechanism of adduct formation has not been fully elucidated. C 8-Arylguanine adducts likely form from direct aryl radical (Ar) addition to the C8 position of guanine. However, the amounts of C 8-aryladenine adducts measured here are inconsistent with direct radical ...