The Journal of organic chemistry

Simple, Rapid Procedure for the Synthesis of Chloromethyl Methyl Ether and Other Chloro Alkyl Ethers1

MA Berliner, K Belecki

Index: Berliner, Martin A.; Belecki, Katherine Journal of Organic Chemistry, 2005 , vol. 70, # 23 p. 9618 - 9621

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Citation Number: 51

Abstract

Zinc (II) salts catalyze the reaction between acetals and acid halides to provide haloalkyl ethers in near-quantitative yield. Reactions from millimole to mole scale are typically complete in 1-4 h with 0.01 mol% catalyst. The solutions of haloalkyl ethers thus obtained can be utilized directly in reactions in which the presence of the ester byproduct does not interfere. Excess haloalkyl ether is destroyed on workup, thereby minimizing exposure to ...