Palladium-Catalyzed Regioselective Carbonylation of C–H Bonds of N-Alkyl Anilines for Synthesis of Isatoic Anhydrides

ZH Guan, M Chen, ZH Ren

Index: Guan, Zheng-Hui; Chen, Ming; Ren, Zhi-Hui Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17490 - 17493,4

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Citation Number: 68

Abstract

A Pd-catalyzed regioselective C–H bond carbonylation of N-alkyl anilines for the synthesis of isatoic anhydrides has been developed. The key Pd-catalyst intermediate has been isolated and characterized. This novel Pd-catalyzed carbonylation reaction tolerates a wide range of functional groups and is a reliable method for the rapid elaboration of readily available N-alkyl anilines into a variety of substituted isatoic anhydrides under mild ...