Continuous flow photocatalysis enhanced using an aluminum mirror: rapid and selective synthesis of 2′-deoxy and 2′, 3′-dideoxynucleosides

…, MW Bedore, A Sniady, TF Jamison

Index: Shen, Bo; Bedore, Matthew W.; Sniady, Adam; Jamison, Timothy F. Chemical Communications, 2012 , vol. 48, # 60 p. 7444 - 7446

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Citation Number: 20

Abstract

A unique photochemical flow reactor featuring quartz tubing, an aluminum mirror and temperature control has been developed for the photo-induced electron-transfer deoxygenation reaction to produce 2′-deoxy and 2′, 3′-dideoxynucleosides. The continuous flow format significantly increased the efficiency and selectivity of the reaction.