Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors

…, A Luppi, A Hatzelmann, P Fossa, L Mosti

Index: Tait, Annalisa; Luppi, Amedeo; Hatzelmann, Armin; Fossa, Paola; Mosti, Luisa Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 4 p. 1393 - 1402

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Citation Number: 9

Abstract

A series of 2, 1, 3-and 1, 2, 4-benzothiadiazine derivatives (BTDs) were synthesized and evaluated for their inhibitory activity versus enzymatic isoforms PDE3, PDE4 and PDE7. The compounds characterized by the 3, 5-di-tert-butyl-4-hydroxybenzyl moiety at N1 position ...