Synthesis of 1, 2, 4-triazole derivatives containing benzothiazoles as pharmacologically active molecule

NB Patel, IH Khan

Index: Patel, Navin B.; Khan, Imran H. Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 4 p. 527 - 534

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Citation Number: 12

Abstract

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3- pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1, 3-benzothiazol-2-amino)-4 H-1, 2, 4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria ( ...