Anti-AIDS agents—XXVI. Structure-activity correlations of gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues
…, Y Kashiwada, BN Zhou, P Wang, LM Cosentino…
Index: Chen, Dao-Feng; Zhang, Shun-Xiang; Xie, Lan; Xie, Jing-Xi; Chen, Ke; Kashiwada, Yoshiki; Zhou, Bing-Nan; Wang, Pei; Cosentino, L. Mark; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 8 p. 1715 - 1723
Full Text: HTML
Citation Number: 174
Abstract
Bioactivity-directed fractionation of an ethanolic extract of the stems of Kadsura interior led to the isolation and identification of 12 known lignans (1–12). Seven of these compounds (1, 6, 8–12) were active as anti-HIV agents. Gomisin-G (11) exhibited the most potent anti-HIV activity with EC50 and therapeutic index (TI) values of 0.006 μg/mL and 300, respectively. Schisantherin-D (6), kadsuranin (8), and schisandrin-C (10) showed good activity with ...
Related Articles:
Process Development of the PDE4 Inhibitor K-34
[Yanagisawa, Arata; Taga, Masashi; Atsumi, Toshiyuki; Nishimura, Koichiro; Ando, Kyoji; Taguchi, Tsuyoshi; Tsumuki, Hiroshi; Chujo, Iwao; Mohri, Shin-Ichiro Organic Process Research and Development, 2011 , vol. 15, # 2 p. 376 - 381]
Process Development of the PDE4 Inhibitor K-34
[Yanagisawa, Arata; Taga, Masashi; Atsumi, Toshiyuki; Nishimura, Koichiro; Ando, Kyoji; Taguchi, Tsuyoshi; Tsumuki, Hiroshi; Chujo, Iwao; Mohri, Shin-Ichiro Organic Process Research and Development, 2011 , vol. 15, # 2 p. 376 - 381]
Process Development of the PDE4 Inhibitor K-34
[Yanagisawa, Arata; Taga, Masashi; Atsumi, Toshiyuki; Nishimura, Koichiro; Ando, Kyoji; Taguchi, Tsuyoshi; Tsumuki, Hiroshi; Chujo, Iwao; Mohri, Shin-Ichiro Organic Process Research and Development, 2011 , vol. 15, # 2 p. 376 - 381]