Organic letters

A highly enantioselective Lewis Basic organocatalyst for reduction of N-aryl imines with unprecedented substrate spectrum

Z Wang, X Ye, S Wei, P Wu, A Zhang, J Sun

Index: Wang, Zhouyu; Ye, Xiaoxia; Wei, Siyu; Wu, Pengcheng; Zhang, Anjiang; Sun, Jian Organic Letters, 2006 , vol. 8, # 5 p. 999 - 1001

Full Text: HTML

Citation Number: 124

Abstract

l-Pipecolinic acid derived formamides have been developed as highly efficient and enantioselective Lewis basic organocatalysts for the reduction of N-aryl imines with trichlorosilane. Catalyst 4b afforded high isolated yields (up to 98%) and enantioselectivities (up to 96%) under mild conditions with an unprecedented substrate spectrum.

Related Articles:

Ti (NMe 2) 4-catalyzed Markovnikov hydroamination of alkynes in the presence of N-heterocyclic carbenes and LiN (SiMe 3) 2

[Takaki, Ken; Koizumi, Sadayuki; Yamamoto, Yuta; Komeyama, Kimihiro Tetrahedron Letters, 2006 , vol. 47, # 41 p. 7335 - 7337]

Synthesis of 2'-Alkylspiro [2-X-cyclohexan-1, 3'-3'H-indole](X= H; X= CH3) by an Unexpected Reaction between an Organomagnesium Halide and 2'-Methylspiro [2-X- …

[Rodriguez, J. Gonzalo; Urrutia, Anahi; De Diego, J. Eugenio; Martinez-Alcazar, M. Paz; Fonseca Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4332 - 4337]

More Articles...