Medicinal Chemistry Research

In silico studies on 2, 3-dihydro-1, 5-benzothiazepines as cholinesterase inhibitors

FL Ansari, S Kalsoom, Z Ali, F Jabeen

Index: Ansari, Farzana Latif; Kalsoom, Saima; Zaheer-Ul-Haq; Ali, Zahra; Jabeen, Farukh Medicinal Chemistry Research, 2012 , vol. 21, # 9 p. 2329 - 2339

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Citation Number: 6

Abstract

Abstract In vitro studies on cholinesterase inhibitory potential on the three sets of 2, 3- dihydro-1, 5-benzothiazepines have been carried out. The compounds in Set 1 were unsubstituted on ring A, while those in Sets 2 and 3 had a 2′-and 3′-hydoxy substituent, respectively, in ring A. These studies revealed that they are mixed inhibitors of both AChE and BChE as reflected from their IC 50 values. It was further observed that 3′-hydroxy ...