Bioorganic & medicinal chemistry

Antiangiogenic and antitumor agents: design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo [2, 3-d] pyrimidines as …

A Gangjee, J Yang, MA Ihnat, S Kamat

Index: Gangjee, Aleem; Yang, Jie; Ihnat, Michael A.; Kamat, Shekhar Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5155 - 5170

Full Text: HTML

Citation Number: 39

Abstract

Several different classes of growth factor receptors containing tyrosine kinases (RTK) are directly or indirectly involved in angiogenesis. Inhibition of these RTKs has provided a new paradigm in the treatment of tumors by restricting their growth and metastasis. We have designed, synthesized and evaluated eleven novel 2-amino-4-(3-bromoanilino)-6- substituted benzyl pyrrolo [2, 3-d] pyrimidines as the first in a series of RTK inhibitors. ...