A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence
D Webb, TF Jamison
Index: Webb, Damien; Jamison, Timothy F. Organic Letters, 2012 , vol. 14, # 10 p. 2465 - 2467
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Citation Number: 13
Abstract
A continuous protocol for the two-carbon homologation of esters to α, β-unsaturated esters is described. This multireactor homologation telescopes an ester reduction, phosphonate deprotonation, and Horner–Wadsworth–Emmons olefination, thus converting a three- operation procedure into a single, uninterrupted system that eliminates the need for isolation or purification of the aldehyde intermediates. The homologated products are obtained in ...
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