Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow …

PB Cranwell, M O'Brien, DL Browne, P Koos…

Index: Cranwell, Philippa B.; O'Brien, Matthew; Browne, Duncan L.; Koos, Peter; Polyzos, Anastasios; Pena-Lopez, Miguel; Ley, Steven V. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 5774 - 5779

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Citation Number: 49

Abstract

Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal–Knorr reaction of 1, 4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.