Tetrahedron

Convenient preparation of substituted 5-aminooxazoles via a microwave-assisted Cornforth rearrangement

…, SL Varga, RT McClain, SE Wolkenberg, CW Lindsley

Index: Nolt, M. Brad; Smiley, Mark A.; Varga, Sandor L.; McClain, Ray T.; Wolkenberg, Scott E.; Lindsley, Craig W. Tetrahedron, 2006 , vol. 62, # 19 p. 4698 - 4704

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Citation Number: 19

Abstract

The preparation of oxazole-4-carboxamides and their subsequent thermal rearrangement to 5-aminooxazole-4-carboxylates is optimized in a high-speed microwave-assisted procedure. The reaction sequence is effective with a variety of substituted oxazoles, and produces products in good yield and high purity.