Tetrahedron letters

Rapid preparation of pyranoquinolines using microwave dielectric heating in combination with fractional product distillation

T Razzaq, CO Kappe

Index: Razzaq, Tahseen; Kappe, C. Oliver Tetrahedron Letters, 2007 , vol. 48, # 14 p. 2513 - 2517

Full Text: HTML

Citation Number: 29

Abstract

4-Hydroxy-6-methyl-2H-pyrano [3, 2-c] quinoline-2, 5 (6H)-dione was prepared by microwave-assisted cyclocondensation of N-methylaniline with 2equiv of diethyl malonate. Key to the success of the synthesis was the use of open vessel controlled microwave heating technology, allowing the simultaneous removal of the formed ethanol from the reaction mixture by fractional distillation.