Flexible and General Synthesis of Functionalized Phosphoisoprenoids for the Study of Prenylation in vivo and in vitro

…, Y Wu, RS Goody, H Waldmann, K Alexandrov

Index: Das, Debapratim; Tnimov, Zakir; Nguyen, Uyen T.T.; Thimmaiah, Govindaraju; Lo, Harriet; Abankwa, Daniel; Wu, Yaowen; Goody, Roger S.; Waldmann, Herbert; Alexandrov, Kirill ChemBioChem, 2012 , vol. 13, # 5 p. 674 - 683

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Citation Number: 11

Abstract

Abstract Protein modification with isoprenoid lipids affects hundreds of signaling proteins in eukaryotic cells. Modification of isoprenoids with reporter groups is the main approach for the creation of probes for the analysis of protein prenylation in vitro and in vivo. Here, we describe a new strategy for the synthesis of functionalized phosphoisoprenoids that uses an aminederivatized isoprenoid scaffold as a starting point for the synthesis of functionalized ...