Defined dimensional alterations in enzyme substrates. Birch reduction of lin-benzopurines. A contribution to information concerning the binding sites of adenosine …

NJ Leonard, A Petric, A Rykowski

Index: Leonard, Nelson J.; Petric, Andrej; Rykowski, Andrzej Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3873 - 3875

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Citation Number: 6

Abstract

An informative approach toward definition of the active sites of enzymes that require purines as substrates or cofactors lies in the use of dimensional probes,'compounds that differ from the natural bases, ribonucleosides, or ribonucleotides by defined dimensional changes. These compounds retain both the pyrimidine and imidazole rings present in purines, but the rings are separated by intervening chemical frameworks. When there is formal insertion of ...