Design and synthesis of 6, 7-dimethoxyquinazoline analogs as multi-targeted ligands for α 1-and AII-receptors antagonism

…, PP Naik, HP Gandhi, BS Chauhan, R Giridhar

Index: Yadav; Naik; Gandhi; Chauhan; Giridhar Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3959 - 3966

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Citation Number: 4

Abstract

Multiple-targeted ligands can have certain advantages for the management of hypertension which has multiple controls. Molecules with dual bioactivities are available in literature for treating metabolic disorders like diabetes, hypertension and hypercholesterolemia. After scrutinizing the SAR of prazosin-type α1-blockers and AII-antagonists it was planned to develop dual α1-and AII-antagonists. Five series of quinazoline derivatives were ...