Heterocycles

One-pot synthesis of 3, 3-dimethylpyrrolidine-2-carbonitriles from 4-chloro-2, 2-dimethylbutanal in water

M D'hooghe, B Van Driessche, N De Kimpe

Index: D'hooghe, Matthias; Van Driessche, Berten; De Kimpe, Norbert Heterocycles, 2009 , vol. 77, # 1 p. 255 - 261

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Abstract

Treatment of 4-chloro-2, 2-dimethylbutanal, prepared in high yield by means of a three-step procedure starting from ethyl isobutyrate, with successively sodium bisulphite, a primary amine and potassium cyanide in water afforded novel 1-alkyl-and 1-aryl-3, 3- dimethylpyrrolidin-2-carbonitriles in a convenient and environmentally benign way.