ClickEnam. 1. Synthesis of novel 1, 4-disubsituted-[1, 2, 3]-triazole-derived β-aminovinyl trifluoromethylated ketones and their copper (II) complexes

N Chopin, S Decamps, A Gouger, M Médebielle…

Index: Chopin, Nicolas; Decamps, Sophie; Gouger, Aude; Medebielle, Maurice; Picot, Stephane; Bienvenu, Anne-Lise; Pilet, Guillaume Journal of Fluorine Chemistry, 2011 , vol. 132, # 10 p. 850 - 857

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Citation Number: 14

Abstract

The copper (I) catalyzed cycloaddition reaction of N-Boc propargyl amine (dipolarophile) 1 with benzyl azide (1, 3-dipole) 2 was found to proceed smoothly in t-BuOH/H2O at room temperature, to furnish the corresponding 1, 4-disubstituted-[1, 2, 3]-triazole-derived N-Boc amine 3 in good yield. Deprotection of 3 with trifluoroacetic acid and addition of the trifluoroacetate salt 4 in the presence of triethylamine, with a series of methoxyvinyl ( ...