Spiro [1, 2, 4-benzotriazine-3 (4H), 4′-(1′-substituted) piperidines] and related compounds as ligands for sigma receptors

F Novelli, F Sparatore

Index: Novelli, Federica; Sparatore, Fabio Farmaco, 2003 , vol. 57, # 11 p. 871 - 882

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Citation Number: 13

Abstract

As analogues of some conformationally restricted spiropiperidine derivatives which are endowed with high affinity for σ1 receptor, a set of 16 spiro [1, 2, 4-benzotriazine-3 (4H), 4′- (1′-substituted) piperidines] and congeneric compounds was prepared and tested for affinity to σ1 receptor subtype. All N-arylalkyl substituted derivatives exhibited high affinity for the relevant receptor, with Ki in the low nanomolar range. Affinity for σ2 subtype (assayed ...