Condensation of monosubstituted isopropylidene malonates with mannich bases

RT Jacobs, AD Wright, FX Smith

Index: Jacobs, Robert T.; Wright, Allen D.; Smith, Francis X. Journal of Organic Chemistry, 1982 , vol. 47, # 19 p. 3769 - 3772

Full Text: HTML

Citation Number: 19

Abstract

I smoothly with decarboxylation upon refluxing with concentrated hydrochloric acid, and the resultant &keto acids were obtained in good yield. Treatment of the products 1 with diethylamine led to a facile carbon-carbon bond cleavage, releasing the monosubstituted malonate and demonstrating the reversibility of these reactions. In the reactions with [(dimethy1amino) methyll ferrocene, TLC indicated considerable product formation after ...