Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity

…, M Kralj, L Šuman, H Stephan, I Piantanida

Index: Noll, Steffi; Kralj, Marijeta; Suman, Lidija; Stephan, Holger; Piantanida, Ivo European Journal of Medicinal Chemistry, 2009 , vol. 44, # 3 p. 1172 - 1179

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Citation Number: 27

Abstract

The antiproliferative activity screening on human tumor cell lines of a series of modified uracil and cytosine bases as well as some corresponding acyclonucleosides, and comparison of structure–activity relationship revealed the importance of chemical reactivity of the substituent attached to the C5-position of uracil for the activity of studied compounds. Namely, the results obtained for the most active compounds, 5-(chloroacetylamino) uracil ( ...