Hydrogenation of Quinaldine and Benzylic Aldehydes both Separately and Combined in a Tandem Hydrogenation–Reductive Alkylation of Quinaldine by Aldehydes …

…, LJ Allen, GE Dobereiner, KC Rippy, N Hazari…

Index: Dobereiner, Graham E.; Nova, Ainara; Schley, Nathan D.; Hazari, Nilay; Miller, Scott J.; Eisenstein, Odile; Crabtree, Robert H. Journal of the American Chemical Society, 2011 , vol. 133, # 19 p. 7547 - 7562

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Citation Number: 5

Abstract

A series of cyclometalated benzoquinoline complexes of Ir (III) catalyze the hydrogenation of the heterocyclic ring of quinolines under mild conditions. Our best catalyst is active in a significantly wider range of solvents than our previous systems. In the presence of a suitable base, the Ir (III) species is also able to hydrogenate the C O bonds of aldehydes. When quinolines and aldehydes are present together, the Ir (III) complex catalyzes a tandem ...