Efficient preparation of polyfunctional. alpha.-diketones from carboxylic acids
R Conrow, PS Portoghese
Index: Conrow, Raymond; Portoghese, Philip S. Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 938 - 940
Full Text: HTML
Citation Number: 42
Abstract
Many enzymes contain an essential arginyl residue at the active site. Butanedione and other simple a-diketones characteristically inactivate these enzymes by bonding covalently to arginine. l In an effort to confer specificity to this interaction, we have sought methods for incorporating an a-diketone moiety into polyfunctional inhibitors of such enzymes. 2 The ideal synthetic method for our purpose would involve the conversion of an existing ...
Related Articles:
[Stergiou, Anastasios; Bariotaki, Anna; Kalaitzakis, Dimitris; Smonou, Ioulia Journal of Organic Chemistry, 2013 , vol. 78, # 14 p. 7268 - 7273]
A novel monoalkylation of symmetrical α-diones
[Gopal, Damodaragounder; Nadkarni, Durgesh V.; Sayre, Lawrence M. Tetrahedron Letters, 1998 , vol. 39, # 14 p. 1877 - 1880]