Sulfonamides incorporating 1, 3, 5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms …

…, A Maresca, J Wagner, BS Avvaru, AH Robbins…

Index: Carta, Fabrizio; Garaj, Vladimir; Maresca, Alfonso; Wagner, Jason; Avvaru, Balendu Sankara; Robbins, Arthur H.; Scozzafava, Andrea; McKenna, Robert; Supuran, Claudiu T. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 10 p. 3105 - 3119

Full Text: HTML

Citation Number: 48

Abstract

Abstract Reaction of cyanuryl chloride with d, l-amino acids and amino alcohols afforded a new series of triazinyl-substituted benzenesulfonamides incorporating amino acyl/hydroxyalkyl-amino moieties. Inhibition studies of physiologically relevant human carbonic anhydrase (CA, EC 4.2. 1.1) isoforms, such as CA I, II, IX, XII and XIV with these compounds are reported. They showed moderate-weak inhibition of the cytosolic, offtarget ...