Tetrahedron letters

Mild and efficient synthesis of carbazates and dithiocarbazates via a three-component coupling using Cs 2 CO 3 and TBAI

DL Fox, JT Ruxer, JM Oliver, KL Alford, RN Salvatore

Index: Fox, Daniel L.; Ruxer, John T.; Oliver, John M.; Alford, Kasey L.; Salvatore, Ralph Nicholas Tetrahedron Letters, 2004 , vol. 45, # 2 p. 401 - 405

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Citation Number: 29

Abstract

Efficient methods for the synthesis of carbazates and dithiocarbazates have been developed. In the presence of cesium carbonate (Cs2CO3) and tetrabutylammonium iodide (TBAI) a hydrazine, CO2 or CS2, and an alkyl halide underwent a three-component coupling at room temperature. Various unprotected hydrazines and alkyl halides were examined and the results demonstrated this methodology was highly chemoselective. Applications ...